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focused their studies on 4,5,4’-trihydroxy-3,3’dimethoxybibenzyl (TDB) from Dendrobium ellipsophyllum and its anti-metastatic effect on lung cancer cells (H292) [ 28]. It was observed that IL-1ra level induced by DH-PS was significantly higher than that by F3, a polysaccharide extract isolated from another popular Chinese herbal medicine, Ganoderma lucidum. sinense showed different degrees of cytotoxicity on SGC-7901, human hepatoma (BEL-7402) and chronic myelogenous leukemia (K562) cell lines. Mitochondrial stress also occurs due to moniliformediquinone action through loss of mitochondrial membrane potential and cytochrome c release, which leads to apoptosis [ 50].
Knowing that Dendrobium drugs have been traditionally used in TCM preparations as a universal remedy, they are worth investigating by scientists who are looking for new natural ingredients, which could become a main feature in healthy aging. huoshanense reduced the levels of some cytokines associated with atopic dermatitis and had beneficial effects on symptoms. A traditional Chinese medicine containing 29 ingredients of which Dendrobium nobile, has been registered to effectively treat diabetes (patent CN105596776). The highest value of IFN-γ was found in splenocyte culture medium treated with 200 mg/mL of HPS-1B23 in the presence of Concanavalin A (ConA) by the end of culture, which was 3.DTP-N represents the major portion of DTP, which might explain why the Mw of DTP and DTP-N were similar to each other, with an average Mw of 305 kDa and 221 kDa, respectively. The hypothesis that bibenzyls compounds may be neuroprotective against apoptosis induced by the neurotoxins has been tested. Twenty-seven patients aged from 4-18 years that had not responded to topical therapy were treated with polysaccharides from D. The sulfation occurred to C-2 and C-6 glucosyl residues seems also to be beneficial to enhance this activity [ 75]. pulchellum, together with chrysotobibenzyl, chrysotoxine and crepidatin showed the ability to facilitate anoikis (a form of programmed cell death) and inhibit the growth of lung cancer cells in anchorage-independent condition, thus they disclosed the inhibitory effect on cancer cell metastasis [ 33].
Most purchases from business sellers are protected by the Consumer Contract Regulations 2013 which give you the right to cancel the purchase within 14 days after the day you receive the item. Significantly decreased AQP-5 protein levels were observed after treatment with TNF-α 100 units/mL for 8hr, but was reversed by the pre-treatment of DP in a dose-dependent manner. The neuroprotective mechanism may also be associated to the inhibition of hyperphosphorylation of tau protein, which could attenuate the dementia symptoms in AD.In SS patients, an over-expression of TNF-α, IL-1β and IL-6 is observed in response to immune-mediated inflammation, as well as an abnormality of aquaporin 5 (AQP-5) in saliva secretion. on the seventh day with 2 g/kg per day oral administration, suggesting that DOP-W3-b is a potent modulator for the production of hematopoietic growth factor. Chrysotoxine showed a significant effect on the attenuation of 6-OHDA-induced apoptosis in SH-SY5Y cells by regulating ROS initiated multiple signaling pathways [ 63].
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