Serum Bicarbonate - D Ball, P L Greenhaff, R J Maughan The acute reversal of a diet-induced metabolic acidosis does not restore endurance capacity during high-intensity exercise in man Eur J Appl Physiol Occup Physiol. (1996) Hypokalaemia (low potassium levels in the blood), symptoms may include anabnormal heartbeat, muscle weakness and numbness. Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist or nurse. This includes any possible side effects not listed in this leaflet. See section 4. Bicarbonate Sodium bicarbonate 500mg capsules (TLS Green) Sodium bicarbonate injection/infusion 1.26%, 2.7%, 8.4% (TLS Green) Hypokalaemia and metabolic alkalosis may occur particularly if renal function is impaired. In severe cases there have been reports of shortness of breath, muscleweakness, convulsions, coma, sodium overloading, hyperosmolality and gastricdamage. Bicarb 500mg Capsules are a safe and effective way to relieve heartburn, indigestion, and upset stomach. They contain sodium bicarbonate, which is a natural antacid that helps to neutralize stomach acid.Discuss your treatment with your doctor before taking this medicine if any of the above applies to you. Taking other medicines Anaerobic Capacity - Robergs R, Hutchinson K, Hendee S, Madden S, Siegler J Influence of pre-exercise acidosis and alkalosis on the kinetics of acid-base recovery following intense exercise Int J Sport Nutr Exerc Metab. (2005 Feb)

Blood Acidity - Taylor DV, Boyajian JG, James N, Woods D, Chicz-Demet A, Wilson AF, Sandman CA Acidosis stimulates beta-endorphin release during exercise J Appl Physiol. (1994 Oct) If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed inthis leaflet You can also report side effects directly via theYellow Card Scheme at: www.mhra.gov.uk/yellowcard. The dose your doctor or pharmacist advises may be different to the doses given in this leaflet. Always follow your doctor or pharmacist’s instructions when taking any medicines. Power Output - Nielsen HB, Bredmose PP, Strømstad M, Volianitis S, Quistorff B, Secher NH Bicarbonate attenuates arterial desaturation during maximal exercise in humans J Appl Physiol. (2002 Aug)The normal concentration range of bicarbonate in plasma is 22 to 32 mmol per litre. The average intake of bicarbonate in the diet is negligible and very little is excreted inthe urine under normal conditions; bicarbonate ions formed in the body are excretedin biliary, intestinal, pancreatic and salivary fluids. If bicarbonate is administeredtherapeutically thus increasing the plasma-bicarbonate concentration above thenormal range then compensatory renal mechanisms come to play and bicarbonate isexcreted in the urine. 5.2 Pharmacokinetic properties Serum Bicarbonate - Kozak-Collins K, Burke ER, Schoene RB Sodium bicarbonate ingestion does not improve performance in women cyclists Med Sci Sports Exerc. (1994 Dec) Teeth Whitening - Mankodi SM, Conforti N, Berkowitz H Efficacy of baking soda-containing chewing gum in removing natural tooth stain Compend Contin Educ Dent. (2001 Jul)

How do I take this medicine? Take Sodium Bicarbonate exactly as directed by your doctor. Do not take more or less than instructed by your doctor. Follow your doctor's instructions carefully. This medicine is available without prescription. Always take this medicine exactly as described in this leaflet or as your doctor, or pharmacist or nurse has have told you. Serum Bicarbonate - L Mc Naughton, D Thompson Acute versus chronic sodium bicarbonate ingestion and anaerobic work and power output J Sports Med Phys Fitness. (2001 Dec)For use for management of hyperphosphataemia in dialysis patients with serum phosphate levels that are not controlled after calcium based binder and sevelamer have been tried or in patients intolerant to other agents Empty the contents of the capsules into a glass of water. Stir until the powder has dissolved and then drink the solution. Muscle weakness and cramps - caused by a disturbance in your body’s pH(alkalosis). This can happen if you take this medicine for long periods of time or ifyou exceed your recommended dose. Do not exceed the recommended dose as excess or prolonged use may lead to alkalosis. 4.5 Interaction with other medicinal products and other forms of interaction